Evaluation and visualization of STR-analysis
GenoProof Mixture uses the new EasyRead technology for evaluation of STR analysis data. This technology enables fast, robust and high-throughput evaluation of your sequencer data (fsa/hid). Even low template stains can easily be evaluated - without time-consuming changes to analysis methods or dependence on the analysis platform. The EasyRead technology supports test kits up to 6-dyes. The software already includes the pre-configured analysis method EasyRead (LRfc) for biostatistical evaluation of stains with the fully continuous model.
Size and Allel Calling
For fast and easy evaluation of STR data, the size and allele calling algorithms now include heuristic optimization for automatic peak detection via polynomial functions. These improvements therefore allow for high throughput analysis.
GenoProof Mixture supports the automatic analysis of autosomal and gonosomal markers with commercial multiplex or in-house kits. The analysis is based on an extensive genetic reference database, including most commercially available STR kits, size standards and markers. The user can add new data with multiple import options.
Graphical User Interface
For the presentation and processing electropherograms, a unique graphic user interface has been developed. The user interface provides pixel perfect resolution, zoom functionalities, as well as various editing and evaluation tools for DNA mixtures. The user can also arrange windows to display electropherograms side by side or beneath each other for comparison of multiple profiles. To simplify analysis of multiple replicates, the marker centric view has been implemented.
GenoProof Mixture supports the complete process of raw data analysis with the help of highly developed algorithms for identification of artefacts. These artefacts include stutter peaks, shoulder peaks, off ladder peaks, off scale peaks and spectral overlap peaks. The artefact detection is included in the size and allele calling, but results can be adjusted by the users.